Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response

Despite the increasing importance of heat shock protein 90 (Hsp90) inhibitors as chemotherapeutic agents in diseases such as cancer, their global effects on the proteome remain largely unknown. Here we use high resolution, quantitative mass spectrometry to map protein expression changes associated w...

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Autori principali: Sharma, Kirti, Vabulas, R. Martin, Macek, Boris, Pinkert, Stefan, Cox, Jürgen, Mann, Matthias, Hartl, F. Ulrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2012
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Special Issue: Prospects in Space and Time
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316734/
https://ncbi.nlm.nih.gov/pubmed/22167270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.014654
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