Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response

Despite the increasing importance of heat shock protein 90 (Hsp90) inhibitors as chemotherapeutic agents in diseases such as cancer, their global effects on the proteome remain largely unknown. Here we use high resolution, quantitative mass spectrometry to map protein expression changes associated w...

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Main Authors: Sharma, Kirti, Vabulas, R. Martin, Macek, Boris, Pinkert, Stefan, Cox, Jürgen, Mann, Matthias, Hartl, F. Ulrich
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Special Issue: Prospects in Space and Time
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316734/
https://ncbi.nlm.nih.gov/pubmed/22167270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.014654
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