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Proteasome Inhibitor Bortezomib Ameliorates Intestinal Injury in Mice

BACKGROUND: Bortezomib is a proteasome inhibitor that has shown impressive efficacy in the treatment of multiple myeloma. In mice, the addition of dextran sulfate sodium (DSS) to drinking water leads to acute colitis that can serve as an experimental animal model for human ulcerative colitis. METHOD...

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Detalhes bibliográficos
Main Authors: Yanaba, Koichi, Asano, Yoshihide, Tada, Yayoi, Sugaya, Makoto, Kadono, Takafumi, Sato, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316702/
https://ncbi.nlm.nih.gov/pubmed/22479648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034587
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