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Proteasome Inhibitor Bortezomib Ameliorates Intestinal Injury in Mice

BACKGROUND: Bortezomib is a proteasome inhibitor that has shown impressive efficacy in the treatment of multiple myeloma. In mice, the addition of dextran sulfate sodium (DSS) to drinking water leads to acute colitis that can serve as an experimental animal model for human ulcerative colitis. METHOD...

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Bibliografiske detaljer
Main Authors: Yanaba, Koichi, Asano, Yoshihide, Tada, Yayoi, Sugaya, Makoto, Kadono, Takafumi, Sato, Shinichi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316702/
https://ncbi.nlm.nih.gov/pubmed/22479648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034587
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