A Possible Contribution of Altered Cathepsin B Expression to the Development of Skin Sclerosis and Vasculopathy in Systemic Sclerosis

Cathepsin B (CTSB) is a proteolytic enzyme potentially modulating angiogenic processes and extracellular matrix remodeling. While matrix metalloproteinases are shown to be implicated in tissue fibrosis and vasculopathy associated with systemic sclerosis (SSc), the role of cathepsins in this disease...

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Autors principals: Noda, Shinji, Asano, Yoshihide, Akamata, Kaname, Aozasa, Naohiko, Taniguchi, Takashi, Takahashi, Takehiro, Ichimura, Yohei, Toyama, Tetsuo, Sumida, Hayakazu, Yanaba, Koichi, Tada, Yayoi, Sugaya, Makoto, Kadono, Takafumi, Sato, Shinichi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285678/
https://ncbi.nlm.nih.gov/pubmed/22384200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032272
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