Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions

Sirtuins and hypoxia-inducible transcription factors (HIF) have well-established roles in regulating cellular responses to metabolic and oxidative stress. Recent reports have linked these two protein families by demonstrating that sirtuins can regulate the activity of HIF-1 and HIF-2. Here we invest...

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Detalhes bibliográficos
Main Authors: Laemmle, Alexander, Lechleiter, Antje, Roh, Vincent, Schwarz, Christa, Portmann, Simone, Furer, Cynthia, Keogh, Adrian, Tschan, Mario P., Candinas, Daniel, Vorburger, Stephan A., Stroka, Deborah
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316573/
https://ncbi.nlm.nih.gov/pubmed/22479397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033433
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