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Comprehensive homing endonuclease target site specificity profiling reveals evolutionary constraints and enables genome engineering applications
Homing endonucleases (HEs) promote the evolutionary persistence of selfish DNA elements by catalyzing element lateral transfer into new host organisms. The high site specificity of this lateral transfer reaction, termed homing, reflects both the length (14–40 bp) and the limited tolerance of target...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315327/ https://ncbi.nlm.nih.gov/pubmed/22121229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1072 |
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