Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

Homing endonucleases (HEs) cut long DNA target sites with high specificity to initiate and target the lateral transfer of mobile introns or inteins. This high site specificity of HEs makes them attractive reagents for gene targeting to promote DNA modification or repair. We have generated several hu...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Li, Hui, Pellenz, Stefan, Ulge, Umut, Stoddard, Barry L., Monnat, Raymond J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655683/
https://ncbi.nlm.nih.gov/pubmed/19153140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp004
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky