Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

Homing endonucleases (HEs) cut long DNA target sites with high specificity to initiate and target the lateral transfer of mobile introns or inteins. This high site specificity of HEs makes them attractive reagents for gene targeting to promote DNA modification or repair. We have generated several hu...

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Bibliografiske detaljer
Main Authors: Li, Hui, Pellenz, Stefan, Ulge, Umut, Stoddard, Barry L., Monnat, Raymond J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655683/
https://ncbi.nlm.nih.gov/pubmed/19153140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp004
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