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Bupropion Binds to Two Sites in the Torpedo Nicotinic Acetylcholine Receptor Transmembrane Domain: A Photoaffinity Labeling Study with the Bupropion Analog [(125)I]-SADU-3-72

Bupropion, a clinically-used antidepressant and smoking-cessation drug, acts as a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). To identify its binding site(s) in nAChRs, we developed a photoreactive bupropion analog, (±)-2-(N-tert-butylamino)-3′-[(125)I]-iodo-4′-azidoprop...

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Autors principals: Pandhare, Akash, Hamouda, Ayman K., Staggs, Brandon, Aggarwal, Shaili, Duddempudi, Phaneendra K., Lever, John R., Lapinsky, David J., Jansen, Michaela, Cohen, Jonathan B., Blanton, Michael P.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315157/
https://ncbi.nlm.nih.gov/pubmed/22394379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300101r
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