(±)-2-(N-tert-Butylamino)-3′-[(125)I]-iodo-4′-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban)

Towards addressing the knowledge gap of how bupropion interacts with the dopamine transporter (DAT) and nicotinic acetylcholine receptors (nAChRs), a ligand was synthesized in which the chlorine of bupropion was isosterically replaced with an iodine and a photoreactive azide was added to the 4′-posi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lapinsky, David J., Aggarwal, Shaili, Nolan, Tammy L., Surratt, Christopher K., Lever, John R., Acharya, Rejwi, Vaughan, Roxanne A., Pandhare, Akash, Blanton, Michael P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249008/
https://ncbi.nlm.nih.gov/pubmed/22119468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.10.086
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