(±)-2-(N-tert-Butylamino)-3′-[(125)I]-iodo-4′-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban)

Towards addressing the knowledge gap of how bupropion interacts with the dopamine transporter (DAT) and nicotinic acetylcholine receptors (nAChRs), a ligand was synthesized in which the chlorine of bupropion was isosterically replaced with an iodine and a photoreactive azide was added to the 4′-posi...

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Autors principals: Lapinsky, David J., Aggarwal, Shaili, Nolan, Tammy L., Surratt, Christopher K., Lever, John R., Acharya, Rejwi, Vaughan, Roxanne A., Pandhare, Akash, Blanton, Michael P.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249008/
https://ncbi.nlm.nih.gov/pubmed/22119468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.10.086
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