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(±)-2-(N-tert-Butylamino)-3′-[(125)I]-iodo-4′-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban)

Towards addressing the knowledge gap of how bupropion interacts with the dopamine transporter (DAT) and nicotinic acetylcholine receptors (nAChRs), a ligand was synthesized in which the chlorine of bupropion was isosterically replaced with an iodine and a photoreactive azide was added to the 4′-posi...

詳細記述

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書誌詳細
主要な著者: Lapinsky, David J., Aggarwal, Shaili, Nolan, Tammy L., Surratt, Christopher K., Lever, John R., Acharya, Rejwi, Vaughan, Roxanne A., Pandhare, Akash, Blanton, Michael P.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249008/
https://ncbi.nlm.nih.gov/pubmed/22119468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.10.086
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