Photoaffinity Labeling the Agonist Binding Domain of α4β4 and α4β2 Neuronal Nicotinic Acetylcholine Receptors with [(125)I]Epibatidine and 5[(125)I]A-85380

The development of nicotinic acetylcholine receptor (nAChR) agonists, particularly those that discriminate between neuronal nAChR subtypes, hold promise as potential therapeutic agents for many neurological diseases and disorders. To this end, we photoaffinity labeled human α4β2 and rat α4β4 nAChRs...

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Detalhes bibliográficos
Main Authors: Hamouda, Ayman K., Jin, Xiaochun, Sanghvi, Mitesh, Srivastava, Shouryadeep, Pandhare, Akash, Duddempudi, Phaneendra K., Steinbach, Joe Henry, Blanton, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744590/
https://ncbi.nlm.nih.gov/pubmed/19545536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2009.06.012
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