[(3)H]Epibatidine Photolabels Non-equivalent Amino Acids in the Agonist Binding Site of Torpedo and α4β2 Nicotinic Acetylcholine Receptors

Nicotinic acetylcholine receptor (nAChR) agonists, such as epibatidine and its molecular derivatives, are potential therapeutic agents for a variety of neurological disorders. In order to identify determinants for subtype-selective agonist binding, it is important to determine whether an agonist bin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Srivastava, Shouryadeep, Hamouda, Ayman K., Pandhare, Akash, Duddempudi, Phaneendra K., Sanghvi, Mitesh, Cohen, Jonathan B., Blanton, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Membrane Transport, Structure, Function, and Biogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757197/
https://ncbi.nlm.nih.gov/pubmed/19620239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.019083
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