Salicylate Downregulates 11β-HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization

Recent trials show salicylates improve glycemic control in type 2 diabetes, but the mechanism is poorly understood. Expression of the glucocorticoid-generating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in adipose tissue is increased in vitro by proinflammatory cytokines and upregulat...

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Главные авторы: Nixon, Mark, Wake, Deborah J., Livingstone, Dawn E., Stimson, Roland H., Esteves, Cristina L., Seckl, Jonathan R., Chapman, Karen E., Andrew, Ruth, Walker, Brian R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2012
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314355/
https://ncbi.nlm.nih.gov/pubmed/22357964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0931
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