Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus

CONTEXT: The mechanism of action of metformin remains unclear. Given the regulation of the cortisol-regenerating enzyme 11βhydroxysteroid dehydrogenase 1 (11βHSD1) by insulin and the limited efficacy of selective 11βHSD1 inhibitors to lower blood glucose when co-prescribed with metformin, we hypothe...

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Pubblicato in:J Clin Endocrinol Metab
Autori principali: Anderson, Anna J., Andrew, Ruth, Homer, Natalie Z., Jones, Gregory C., Smith, Kenneth, Livingstone, Dawn E., Walker, Brian R., Stimson, Roland H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2016
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052341/
https://ncbi.nlm.nih.gov/pubmed/27459533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2016-2069
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