Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition

OBJECTIVE: The cortisol-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies glucocorticoid levels in liver and adipose tissue. 11β-HSD1 inhibitors are being developed to treat type 2 diabetes. In obesity, 11β-HSD1 is increased in adipose tissue but decreased in liver. Th...

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Autori principali: Stimson, Roland H., Andrew, Ruth, McAvoy, Norma C., Tripathi, Dhiraj, Hayes, Peter C., Walker, Brian R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2011
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046832/
https://ncbi.nlm.nih.gov/pubmed/21266326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0726
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