Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans

OBJECTIVE—11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates cortisol from cortisone. 11β-HSD1 mRNA and activity are increased in vitro in subcutaneous adipose tissue from obese patients. Inhibition of 11β-HSD1 is a promising therapeutic approach in type 2 diabetes. However, release of c...

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Главные авторы: Stimson, Roland H., Andersson, Jonas, Andrew, Ruth, Redhead, Doris N., Karpe, Fredrik, Hayes, Peter C., Olsson, Tommy, Walker, Brian R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2009
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606892/
https://ncbi.nlm.nih.gov/pubmed/18852329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0969
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