Simvastatin Reduces Steroidogenesis by Inhibiting Cyp17a1 Gene Expression in Rat Ovarian Theca-Interstitial Cells

Polycystic ovary syndrome (PCOS) is characterized by ovarian enlargement, theca-interstitial hyperplasia, and increased androgen production by theca cells. Previously, our group has demonstrated that statins (competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, a rate-limiting...

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Detaylı Bibliyografya
Asıl Yazarlar: Ortega, Israel, Cress, Amanda B., Wong, Donna H., Villanueva, Jesus A., Sokalska, Anna, Moeller, Ben C., Stanley, Scott D., Duleba, Antoni J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for the Study of Reproduction, Inc. 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3313666/
https://ncbi.nlm.nih.gov/pubmed/21918126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.111.094714
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