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Synthesis of 5′ cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N(7))-methyl transferase
The 5′ end of eukaryotic mRNA carries a N(7)-methylguanosine residue linked by a 5′-5′ triphosphate bond. This cap moiety ((7m)GpppN) is an essential RNA structural modification allowing its efficient translation, limiting its degradation by cellular 5′ exonucleases and avoiding its recognition as “...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3312571/ https://ncbi.nlm.nih.gov/pubmed/22334760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.030932.111 |
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