Hydrocortisone normalizes oxygenation and cGMP regulation in lambs with persistent pulmonary hypertension of the newborn

In the pulmonary vasculature, cGMP levels are regulated by soluble guanylate cyclase (sGC) and phosphodiesterase 5 (PDE5). We previously reported that lambs with persistent pulmonary hypertension of the newborn (PPHN) demonstrate increased reactive oxygen species (ROS) and altered sGC and PDE5 activ...

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Autori principali: Perez, Marta, Lakshminrusimha, Satyan, Wedgwood, Stephen, Czech, Lyubov, Gugino, Sylvia F., Russell, James A., Farrow, Kathryn N., Steinhorn, Robin H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311533/
https://ncbi.nlm.nih.gov/pubmed/22198909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00145.2011
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