SOD and inhaled nitric oxide normalize phosphodiesterase 5 expression and activity in neonatal lambs with persistent pulmonary hypertension

Phosphodiesterase 5 (PDE5) and soluble guanylate cyclase (sGC) are key regulators of cGMP and pulmonary vascular tone. We sought to determine the impact of mechanical ventilation with O(2) with or without inhaled nitric oxide (iNO) or recombinant human Cu/Zn SOD (rhSOD) on sGC, PDE5, and cGMP in the...

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Bibliografiset tiedot
Päätekijät: Farrow, Kathryn N., Lakshminrusimha, Satyan, Czech, Lyubov, Groh, Beezly S., Gugino, Sylvia F., Davis, Jonathan M., Russell, James A., Steinhorn, Robin H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2010
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904095/
https://ncbi.nlm.nih.gov/pubmed/20400523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00309.2009
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