SOD and inhaled nitric oxide normalize phosphodiesterase 5 expression and activity in neonatal lambs with persistent pulmonary hypertension

Phosphodiesterase 5 (PDE5) and soluble guanylate cyclase (sGC) are key regulators of cGMP and pulmonary vascular tone. We sought to determine the impact of mechanical ventilation with O(2) with or without inhaled nitric oxide (iNO) or recombinant human Cu/Zn SOD (rhSOD) on sGC, PDE5, and cGMP in the...

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Main Authors: Farrow, Kathryn N., Lakshminrusimha, Satyan, Czech, Lyubov, Groh, Beezly S., Gugino, Sylvia F., Davis, Jonathan M., Russell, James A., Steinhorn, Robin H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904095/
https://ncbi.nlm.nih.gov/pubmed/20400523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00309.2009
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