SOD and inhaled nitric oxide normalize phosphodiesterase 5 expression and activity in neonatal lambs with persistent pulmonary hypertension

Phosphodiesterase 5 (PDE5) and soluble guanylate cyclase (sGC) are key regulators of cGMP and pulmonary vascular tone. We sought to determine the impact of mechanical ventilation with O(2) with or without inhaled nitric oxide (iNO) or recombinant human Cu/Zn SOD (rhSOD) on sGC, PDE5, and cGMP in the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Farrow, Kathryn N., Lakshminrusimha, Satyan, Czech, Lyubov, Groh, Beezly S., Gugino, Sylvia F., Davis, Jonathan M., Russell, James A., Steinhorn, Robin H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2010
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904095/
https://ncbi.nlm.nih.gov/pubmed/20400523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00309.2009
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