Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice

Our previous data showed the inhibitory effect of ethanol on AMP-activated protein kinase phosphorylation, which appears to be mediated, in part, through increased levels of hepatic ceramide and activation of protein phosphatase 2A (Liangpunsakul S, Sozio MS, Shin E, Zhao Z, Xu Y, Ross RA, Zeng Y, C...

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Autores principales: Liangpunsakul, Suthat, Rahmini, Yasmeen, Ross, Ruth A., Zhao, Zhenwen, Xu, Yan, Crabb, David W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2012
Materias:
Liver and Biliary Tract
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311438/
https://ncbi.nlm.nih.gov/pubmed/22194417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00455.2011
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