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Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice

Our previous data showed the inhibitory effect of ethanol on AMP-activated protein kinase phosphorylation, which appears to be mediated, in part, through increased levels of hepatic ceramide and activation of protein phosphatase 2A (Liangpunsakul S, Sozio MS, Shin E, Zhao Z, Xu Y, Ross RA, Zeng Y, C...

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Detalhes bibliográficos
Main Authors: Liangpunsakul, Suthat, Rahmini, Yasmeen, Ross, Ruth A., Zhao, Zhenwen, Xu, Yan, Crabb, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311438/
https://ncbi.nlm.nih.gov/pubmed/22194417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00455.2011
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