APOBEC3G-Induced Hypermutation of Human Immunodeficiency Virus Type-1 Is Typically a Discrete “All or Nothing” Phenomenon

The rapid evolution of Human Immunodeficiency Virus (HIV-1) allows studies of ongoing host–pathogen interactions. One key selective host factor is APOBEC3G (hA3G) that can cause extensive and inactivating Guanosine-to-Adenosine (G-to-A) mutation on HIV plus-strand DNA (termed hypermutation). HIV can...

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Hauptverfasser: Armitage, Andrew E., Deforche, Koen, Chang, Chih-hao, Wee, Edmund, Kramer, Beatrice, Welch, John J., Gerstoft, Jan, Fugger, Lars, McMichael, Andrew, Rambaut, Andrew, Iversen, Astrid K. N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310730/
https://ncbi.nlm.nih.gov/pubmed/22457633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002550
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