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Hypermutation of apoB mRNA by rat APOBEC-1 over-expression mimicks APOBEC-3 hypermutation
APOBEC-3 proteins induce C-to-U hypermutations in the viral genome of various viruses and have broad antiviral activity. Generally only a small proportion of viral genomes (≤10(−2)) are hypermutated by APOBEC-3s but often many cytidines (up to 40%) are converted to uridine. The mechanism of this uni...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3311742/ https://ncbi.nlm.nih.gov/pubmed/22326345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.02.005 |
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