Hypermutation of apoB mRNA by rat APOBEC-1 over-expression mimicks APOBEC-3 hypermutation

APOBEC-3 proteins induce C-to-U hypermutations in the viral genome of various viruses and have broad antiviral activity. Generally only a small proportion of viral genomes (≤10(−2)) are hypermutated by APOBEC-3s but often many cytidines (up to 40%) are converted to uridine. The mechanism of this uni...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Zhigang, Eggerman, Thomas L., Bocharov, Alexander V., Baranova, Irina N., Vishnyakova, Tatyana G., Kurlander, Roger J., Csako, Gyorgy, Patterson, Amy P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311742/
https://ncbi.nlm.nih.gov/pubmed/22326345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.02.005
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