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Hypermutation induced by APOBEC-1 overexpression can be eliminated
APOBEC-1 overexpression in liver has been shown to effectively reduce apoB-100 levels. However, nonspecific hypermutation and liver tumor formation potentially related to hypermutation in transgenic animals compromise its potential use for gene therapy. In studying apoB mRNA editing regulation, we f...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856876/ https://ncbi.nlm.nih.gov/pubmed/20348446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1863010 |
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