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Hypermutation induced by APOBEC-1 overexpression can be eliminated
APOBEC-1 overexpression in liver has been shown to effectively reduce apoB-100 levels. However, nonspecific hypermutation and liver tumor formation potentially related to hypermutation in transgenic animals compromise its potential use for gene therapy. In studying apoB mRNA editing regulation, we f...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Cold Spring Harbor Laboratory Press
2010
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856876/ https://ncbi.nlm.nih.gov/pubmed/20348446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1863010 |
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