Possible Footprints of APOBEC3F and/or Other APOBEC3 Deaminases, but Not APOBEC3G, on HIV-1 from Patients with Acute/Early and Chronic Infections

Members of the apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like-3 (APOBEC3) innate cellular cytidine deaminase family, particularly APOBEC3F and APOBEC3G, can cause extensive and lethal G-to-A mutations in HIV-1 plus-strand DNA (termed hypermutation). It is unclear if APOBEC3-induced...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Armitage, Andrew E., Deforche, Koen, Welch, John J., Van Laethem, Kristel, Camacho, Ricardo, Rambaut, Andrew, Iversen, Astrid K. N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248940/
https://ncbi.nlm.nih.gov/pubmed/25165112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01460-14
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