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Purification, crystallization and preliminary X-ray diffraction analysis of the Fyn SH2 domain and its complex with a phosphotyrosine peptide

SH2 domains are widespread protein-binding modules that recognize phosphotyrosines and play central roles in intracellular signalling pathways. The SH2 domain of the human protein tyrosine kinase Fyn has been expressed, purified and crystallized in the unbound state and in complex with a high-affini...

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書誌詳細
主要な著者: Huculeci, Radu, Buts, Lieven, Lenaerts, Tom, van Nuland, Nico A. J., Garcia-Pino, Abel
フォーマット: Artigo
言語:Inglês
出版事項: International Union of Crystallography 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310552/
https://ncbi.nlm.nih.gov/pubmed/22442244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112004186
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