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Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase

The C-terminal Src kinase (Csk) and Csk-homologous kinase (CHK) are endogenous inhibitors of the proto-oncogenic Src family of protein tyrosine kinases (SFKs). Phosphotyrosyl peptide binding to their Src-homology 2 (SH2) domains activates Csk and CHK, enhancing their ability to suppress SFK signalli...

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Detaylı Bibliyografya
Asıl Yazarlar: Gunn, Natalie J., Gorman, Michael A., Dobson, Renwick C. J., Parker, Michael W., Mulhern, Terrence D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: International Union of Crystallography 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053158/
https://ncbi.nlm.nih.gov/pubmed/21393838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110053728
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