End-Point Immobilization of Recombinant Thrombomodulin via Sortase-Mediated Ligation

We report an enzymatic end-point modification and immobilization of recombinant human thrombomodulin (TM), a cofactor for activation of anticoagulant protein C pathway via thrombin. First, a truncated TM mutant consisting of epidermal growth factor-like domains 4–6 (TM(456)) with a conserved pentape...

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Bibliografiske detaljer
Main Authors: Jiang, Rui, Weingart, Jacob, Zhang, Hailong, Ma, Yong, Sun, Xue-Long
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310247/
https://ncbi.nlm.nih.gov/pubmed/22372933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200661w
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