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Recombinant and Chemo-/Bio-Orthogonal Synthesis of Liposomal Thrombomodulin and Its Antithrombotic Activity
Thrombomodulin (TM) is an endothelial cell membrane protein that acts as a major cofactor in the protein C anticoagulant pathway. The EGF-like domains 4–6 of TM (TM(456)) are essential for PC activation. In this study, we proposed a liposomal recombinant TM conjugate to mimic the membrane TM structu...
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| 發表在: | J Biosci Bioeng |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5591061/ https://ncbi.nlm.nih.gov/pubmed/28694021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiosc.2017.05.008 |
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