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End-point Modification of Recombinant Thrombomodulin with Enhanced Stability and Anticoagulant Activity
Thrombomodulin (TM) is an endothelial cell membrane protein that plays essential roles in controlling vascular haemostatic balance. The 4, 5, 6 EGF-like domain of TM (TM(456)) has cofactor activity for thrombin binding and subsequently protein C activation. Therefore, recombinant TM(456) is a promis...
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| Veröffentlicht in: | Eur J Pharm Sci |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6767613/ https://ncbi.nlm.nih.gov/pubmed/31513922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2019.105066 |
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