Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

[Image: see text] In an effort to identify a new class of druglike HIV-1 protease inhibitors, four different stereopure β-hydroxy γ-lactam-containing inhibitors have been synthesized, biologically evaluated, and cocrystallized. The impact of the tether length of the central spacer (two or three carb...

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Auteurs principaux: Wu, Xiongyu, Öhrngren, Per, Joshi, Advait A., Trejos, Alejandro, Persson, Magnus, Arvela, Riina K., Wallberg, Hans, Vrang, Lotta, Rosenquist, Åsa, Samuelsson, Bertil B., Unge, Johan, Larhed, Mats
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2012
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310203/
https://ncbi.nlm.nih.gov/pubmed/22376008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201620t
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