Polymorphisms in HSD17B1: Early Onset and Increased Risk of Alzheimer's Disease in Women with Down Syndrome

Background/Aims. Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). In women with Down syndrome, we examined the relation of polymorphisms in hydroxysteroid-17beta-dehydrogenase (HSD17B1) to age at onset and risk of AD. HSD17B1 encodes the enzyme...

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Detalhes bibliográficos
Main Authors: Lee, Joseph H., Gurney, Susan, Pang, Deborah, Temkin, Alexis, Park, Naeun, Janicki, Sarah C., Zigman, Warren B., Silverman, Wayne, Tycko, Benjamin, Schupf, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310186/
https://ncbi.nlm.nih.gov/pubmed/22474448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/361218
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