Variants in CYP17 and CYP19 Cytochrome P450 genes are associated with onset of Alzheimer’s disease in women with Down syndrome

CYP17and CYP19 are involved in the peripheral synthesis of estrogens, and polymorphisms in CYP17 and CYP19 have been associated with increased risk of estrogen-related disorders. Women with Down syndrome (DS) have early onset and high risk for Alzheimer’s disease (AD). We conducted a prospective com...

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Autori principali: Chace, Constance, Pang, Deborah, Weng, Catherine, Temkin, Alexis, Lax, Simon, Silverman, Wayne, Zigman, Warren, Ferin, Michel, Lee, Joseph H., Tycko, Benjamin, Schupf, Nicole
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276705/
https://ncbi.nlm.nih.gov/pubmed/22057025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-110860
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