Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing

Mint adaptor proteins bind to the amyloid precursor protein (APP) and regulate APP processing associated with Alzheimer’s disease; however, the molecular mechanisms underlying Mint regulation in APP binding and processing remain unclear. Biochemical, biophysical, and cellular experiments now show th...

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Detalhes bibliográficos
Main Authors: Matos, Maria F., Xu, Yibin, Dulubova, Irina, Otwinowski, Zbyszek, Richardson, John M., Tomchick, Diana R., Rizo, Josep, Ho, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309763/
https://ncbi.nlm.nih.gov/pubmed/22355143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119075109
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