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Mint Proteins Are Required for Synaptic Activity-dependent Amyloid Precursor Protein (APP) Trafficking and Amyloid β Generation

Aberrant amyloid β (Aβ) production plays a causal role in Alzheimer disease pathogenesis. A major cellular pathway for Aβ generation is the activity-dependent endocytosis and proteolytic cleavage of the amyloid precursor protein (APP). However, the molecules controlling activity-dependent APP traffi...

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Bibliografiska uppgifter
Huvudupphovsmän: Sullivan, Sarah E., Dillon, Gregory M., Sullivan, Josefa M., Ho, Angela
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140894/
https://ncbi.nlm.nih.gov/pubmed/24742670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541003
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