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Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage

Amyloid-β precursor protein (APP), a type I membrane protein, is physiologically processed by α- or β-secretases that cleave APP N-terminal to the transmembrane region. Extracellular α-/β-cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment. Subs...

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Detalhes bibliográficos
Main Authors: Ho, Angela, Südhof, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC356987/
https://ncbi.nlm.nih.gov/pubmed/14983046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308655100
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