Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy

BACKGROUND: Cyclin-dependent kinases (CDKs) regulate cell proliferation and coordinate the cell cycle checkpoint response to DNA damage. Although inhibitors with varying selectivity to specific CDK family members have been developed, selective CDK4/6 inhibitors have emerged as the most attractive an...

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Hauptverfasser: Roberts, Patrick J., Bisi, John E., Strum, Jay C., Combest, Austin J., Darr, David B., Usary, Jerry E., Zamboni, William C., Wong, Kwok-Kin, Perou, Charles M., Sharpless, Norman E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309128/
https://ncbi.nlm.nih.gov/pubmed/22302033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djs002
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