Predicting drug responsiveness in human cancers using genetically engineered mice

PURPOSE: To use genetically engineered mouse models (GEMMs) and orthotopic syngeneic murine transplants (OSTs) to develop gene-expression based predictors of response to anti-cancer drugs in human tumors. These mouse models offer advantages including precise genetics and an intact microenvironment/i...

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Detalhes bibliográficos
Main Authors: Usary, Jerry, Zhao, Wei, Darr, David, Roberts, Patrick J., Liu, Mei, Balletta, Lorraine, Karginova, Olga, Jordan, Jamie, Combest, Austin, Bridges, Arlene, Prat, Aleix, Cheang, Maggie C. U., Herschkowitz, Jason I., Rosen, Jeffrey M., Zamboni, William, Sharpless, Norman E., Perou, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778918/
https://ncbi.nlm.nih.gov/pubmed/23780888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0522
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