Kaiso uses all Three Zinc Fingers and Adjacent Sequence Motifs for High Affinity Binding to Sequence-specific and Methyl-CpG DNA Targets

Kaiso is a Cys(2)His(2) zinc finger protein that mediates methyl-CpG -dependent and sequence-specific transcriptional repression. As a first step towards elucidating the structural and molecular basis for recognition of these disparate DNA sequences, the minimal binding region of Kaiso was identifie...

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Main Authors: Buck-Koehntop, Bethany A., Martinez-Yamout, Maria A., Dyson, H. Jane, Wright, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309074/
https://ncbi.nlm.nih.gov/pubmed/22300642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.01.045
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