Novel Role for Non-muscle Myosin Light Chain Kinase (MLCK) in Hyperoxia-induced Recruitment of Cytoskeletal Proteins, NADPH Oxidase Activation, and Reactive Oxygen Species Generation in Lung Endothelium

We recently demonstrated that hyperoxia (HO) activates lung endothelial cell NADPH oxidase and generates reactive oxygen species (ROS)/superoxide via Src-dependent tyrosine phosphorylation of p47(phox) and cortactin. Here, we demonstrate that the non-muscle ∼214-kDa myosin light chain (MLC) kinase (...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Usatyuk, Peter V., Singleton, Patrick A., Pendyala, Srikanth, Kalari, Satish K., He, Donghong, Gorshkova, Irina A., Camp, Sara M., Moitra, Jaideep, Dudek, Steven M., Garcia, Joe G. N., Natarajan, Viswanathan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308820/
https://ncbi.nlm.nih.gov/pubmed/22219181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.294546
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