Novel Role for Non-muscle Myosin Light Chain Kinase (MLCK) in Hyperoxia-induced Recruitment of Cytoskeletal Proteins, NADPH Oxidase Activation, and Reactive Oxygen Species Generation in Lung Endothelium

We recently demonstrated that hyperoxia (HO) activates lung endothelial cell NADPH oxidase and generates reactive oxygen species (ROS)/superoxide via Src-dependent tyrosine phosphorylation of p47(phox) and cortactin. Here, we demonstrate that the non-muscle ∼214-kDa myosin light chain (MLC) kinase (...

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Detalhes bibliográficos
Main Authors: Usatyuk, Peter V., Singleton, Patrick A., Pendyala, Srikanth, Kalari, Satish K., He, Donghong, Gorshkova, Irina A., Camp, Sara M., Moitra, Jaideep, Dudek, Steven M., Garcia, Joe G. N., Natarajan, Viswanathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308820/
https://ncbi.nlm.nih.gov/pubmed/22219181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.294546
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