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Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function

BACKGROUND: One of two proapoptotic Bcl-2 proteins, Bak or Bax, is required to permeabilize the mitochondrial outer membrane during apoptosis. While Bax is mostly cytosolic and translocates to mitochondria following an apoptotic stimulus, Bak is constitutively integrated within the outer membrane. M...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ferrer, Pedro Eitz, Frederick, Paul, Gulbis, Jacqueline M., Dewson, Grant, Kluck, Ruth M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307716/
https://ncbi.nlm.nih.gov/pubmed/22442658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031510
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