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BAK/BAX activation and cytochrome c release assays using isolated mitochondria

The mitochondrial pathway of apoptosis proceeds when the outer mitochondrial membrane (OMM) is compromised by the pro-apoptotic BCL-2 family members, BAK and BAX. Once activated, BAK and BAX form proteolipid pores in the OMM leading to mitochondrial outer membrane permeabilization (MOMP), and the re...

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Bibliografische gegevens
Hoofdauteurs: Renault, Thibaud T., Floros, Konstantinos V., Chipuk, Jerry E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686896/
https://ncbi.nlm.nih.gov/pubmed/23567751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2013.03.030
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