Long-Lasting Effects of a PEGylated Mutant Cocaine Esterase (CocE) on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rats

Recent mutagenesis studies have identified a mutant G4C/S10C/T172R/G173Q cocaine esterase (CCRQ CocE) with an in vitro duration of action of >40 days. Although the in vivo duration of CCRQ CocE's action was <24 h, modification of this enzyme with polyethylene glycol (PEG) polymers resulte...

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Autores principales: Collins, Gregory T, Narasimhan, Diwahar, Cunningham, Alyssa R, Zaks, Matthew E, Nichols, Joseph, Ko, Mei-Chuan, Sunahara, Roger K, Woods, James H
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306869/
https://ncbi.nlm.nih.gov/pubmed/21993206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.226
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