Long-Lasting Effects of a PEGylated Mutant Cocaine Esterase (CocE) on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rats

Recent mutagenesis studies have identified a mutant G4C/S10C/T172R/G173Q cocaine esterase (CCRQ CocE) with an in vitro duration of action of >40 days. Although the in vivo duration of CCRQ CocE's action was <24 h, modification of this enzyme with polyethylene glycol (PEG) polymers resulte...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Collins, Gregory T, Narasimhan, Diwahar, Cunningham, Alyssa R, Zaks, Matthew E, Nichols, Joseph, Ko, Mei-Chuan, Sunahara, Roger K, Woods, James H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306869/
https://ncbi.nlm.nih.gov/pubmed/21993206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.226
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados