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Agonism/antagonism switching in allosteric ensembles

Ligands for several transcription factors can act as agonists under some conditions and antagonists under others. The structural and molecular bases of such effects are unknown. Previously, we demonstrated how the folding of intrinsically disordered (ID) protein sequences, in particular, and populat...

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Bibliografiske detaljer
Main Authors: Motlagh, Hesam N., Hilser, Vincent J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306695/
https://ncbi.nlm.nih.gov/pubmed/22388747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120519109
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