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Design of protein switches based on an ensemble model of allostery
Switchable proteins that can be regulated through exogenous or endogenous inputs have a broad range of biotechnological and biomedical applications. Here we describe the design of switchable enzymes based on an ensemble allosteric model. First, we insert an enzyme domain into an effector-binding dom...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704092/ https://ncbi.nlm.nih.gov/pubmed/25902417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7968 |
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